Recombinant mouse MESDC2 protein
MESDC2 also known as LDLR chaperone MESD. This protein is specialized chaperone for low-density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6. Furthermore, MESDC2 plays an essential role in NMJ formation by promoting Lrp4 maturation. Recombinant mouse MESDC2, fused to His-tag at N-terminus was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
2210015O11Rik, AW537813, mesd, mKIAA0081, msd
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Purity
> 90% by SDS-PAGE
Molecular Weight
24.4 kDa (218aa)
Additionnal Information
References & Citations
Lu W., et al. (2010) Biochemistry. 49 (22) : 4635-43.; ; Hoshi T., et al. (2013) FEBS Lett. 587 (23) : 3749-54.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_075892
Uniprot Accession Number
Q9ERE7
Species
Mouse
AA Sequence
Frequently Asked Questions
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