Recombinant human IL-6 protein

IL6, also known as interleukin 6. It is a cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. This protein plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. Recombinant human IL6 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Human IL-6 in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 range ≤ 1 ng/mL.

Product Name Alternative

Interleukin-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2, IFNB2, HGF, HSF

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE, Bioactivity

Concentration

0.5 mg/mL (determined by BCA assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Bioactivity

Measured in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 range ≤ 1 ng/mL.

Molecular Weight

20.9 kDa (184aa)

Additionnal Information

VLAB, VLA-4 subunit bet, VLA4 subunit bet, VLA 4 subunit bet, MSK12, MSK 12, MDF2, Interleukin-6, Interleukin6, Interleukin 6, Interferon beta 2, Integrin beta1, Integrin beta 1, IL-6, IL6, IL 6, IFNB2, IFNB 2, IFN B2, IFN B 2, I L6, HSF, HGF, GPIIA, GP IIA, Glycoprotein Iia, FNRB, Fibronectin receptor subunit beta, CD29, BSF2, BSF 2, ATGP3256-10 µg, ATGP3256-20 µg, ATGP3256-50 µg, ATGP3256-100 µg, ATGP3256-250 µg, ATGP3256-500 µg, ATGP3256-1 mg, ATGP3256-010, ATGP3256-020, ATGP3256-050, ATGP3256-100, ATGP3256-250, ATGP3256-500, ATGP3256-01M

References & Citations

May L T., et al. (1991) Cytokine 3 (3) :204-211.

Other References

Yang YJ et al., Korean Mistletoe (Viscum album var. coloratum) Ethanol Extracts Enhance Intestinal Barrier Function and Alleviate Inflammation. (Antioxidants (Basel) 2025) {https://pubmed.ncbi.nlm.nih.gov/40227441}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4)

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_000591

Uniprot Accession Number

P05231

Species

Human

AA Sequence

MVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM