Recombinant human Erythropoietin R/EPOR protein

EPOR, also known as Erythropoietin receptor, mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, it dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. So it may also activate the LYN tyrosine kinase. Recombinant human EPOR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

EPO-R, EPOR, Erythropoietin receptor

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

25.6 kDa (232aa)

Additionnal Information

Erythropoietin R, EPO-R, EPOR, ATGP3252-10 µg, ATGP3252-20 µg, ATGP3252-50 µg, ATGP3252-100 µg, ATGP3252-250 µg, ATGP3252-500 µg, ATGP3252-1 mg, ATGP3252-10, ATGP3252-20, ATGP3252-50, ATGP3252-100, ATGP3252-250, ATGP3252-500, ATGP3252-1

References & Citations

Nakamura Y., et al. (1992) Science. 257:1138-1141.; ; Kirito K., et al. (2002) Blood. 99:102-110.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_000112

Uniprot Accession Number

P19235

Species

Human

AA Sequence

APPPNLPDPK FESKAALLAA RGPEELLCFT ERLEDLVCFW EEAASAGVGP GNYSFSYQLE DEPWKLCRLH QAPTARGAVR FWCSLPTADT SSFVPLELRV TAASGAPRYH RVIHINEVVL LDAPVGLVAR LADESGHVVL RWLPPPETPM TSHIRYEVDV SAGNGAGSVQ RVEILEGRTE CVLSNLRGRT RYTFAVRARM AEPSFGGFWS AWSEPVSLLT PSDLDPHHHH HH