Recombinant human IL-3RB/CSF2RB protein

CSF2RB, also known as cytokine receptor common subunit beta, is a high affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors, providing a structural basis for understanding their mechanism of activation and for the development of therapeutics. Recombinant human CSF2RB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Colony stimulating factor 2 receptor subunit beta, Cytokine receptor common subunit beta, Beta common cytokine receptor, Beta-GM-CSF receptor, GM-CSF/IL-3/IL-5 receptor common beta subunit, IL5RB, CD131, BetaGMR

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

49.7 kDa (435aa)

Additionnal Information

Common b Chain, CD131, CDw131, IL3RB, IL5RB, SMDP5, CSF2RB, ATGP3244-10 µg, ATGP3244-20 µg, ATGP3244-50 µg, ATGP3244-100 µg, ATGP3244-250 µg, ATGP3244-500 µg, ATGP3244-1 mg, ATGP3244-10, ATGP3244-20, ATGP3244-50, ATGP3244-100, ATGP3244-250, ATGP3244-500, ATGP3244-1

References & Citations

Hansen G., et al. (2008) Cell. 134:496-507.; ; Mulhern TD., et al. (2000) J Mol Biol. 297:989-1001.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_000386

Uniprot Accession Number

P32927

Species

Human

AA Sequence

WERSLAGAEE TIPLQTLRCY NDYTSHITCR WADTQDAQRL VNVTLIRRVN EDLLEPVSCD LSDDMPWSAC PHPRCVPRRC VIPCQSFVVT DVDYFSFQPD RPLGTRLTVT LTQHVQPPEP RDLQISTDQD HFLLTWSVAL GSPQSHWLSP GDLEFEVVYK RLQDSWEDAA ILLSNTSQAT LGPEHLMPSS TYVARVRTRL APGSRLSGRP SKWSPEVCWD SQPGDEAQPQ NLECFFDGAA VLSCSWEVRK EVASSVSFGL FYKPSPDAGE EECSPVLREG LGSLHTRHHC QIPVPDPATH GQYIVSVQPR RAEKHIKSSV NIQMAPPSLN VTKDGDSYSL RWETMKMRYE HIDHTFEIQY RKDTATWKDS KTETLQNAHS MALPALEPST RYWARVRVRT SRTGYNGIWS EWSEARSWDT ESVLPMWLEH HHHHH