Recombinant mouse WIF-1 protein
WIF1, also known as wnt inhibitory factor 1, is a secreted protein that binds to Wnt proteins and inhibits their activities. This protein signaling plays a pivotal role in skeletal development and in the control of cartilage and bone turnover. Also, WIF1 is present in fish, amphibia and mammals, and is expressed during Xenopus and zebrafish development in a complex pattern that includes paraxial presomitic mesoderm, notochord, branchial arches and neural crest derivatives. Recombinant mouse WIF1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Wif-1, WIF-1, AW107799
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
39.4 kDa (359aa)
Additionnal Information
References & Citations
Park JH., et al. (2014) Dev. Biol. 386 (1) :227-236.; ; Stock M., et al. (2013) Arthritis Rheum. 65 (9) :2310-2322.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM MES buffer (pH 5.5) containing 1mM DTT, 1mM PMSF, 30% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_036045
Uniprot Accession Number
Q9WUA1
Species
Mouse
AA Sequence
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