Recombinant human GITR/TNFRSF18 protein
TNFRSF18, also known as tumor necrosis factor receptor superfamily member 18, belongs to the tumor necrosis factor receptor superfamily. It is receptor for TNFSF18 and seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It is mediated NF-kappa-B activation via the TRAF2/NIK pathway. Recombinant human TNFRSF18, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
15.6 kDa (145aa)
Additionnal Information
References & Citations
Gurney A.L., et al. (1999) Curr. Biol. 9:215-218.; ; Kwon B., et al. (1999) J.Biol. Chem. 274:6056-6061.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_004186
Uniprot Accession Number
Q9Y5U5
Species
Human
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