Recombinant human IL-1R alpha/IL1R1 protein
IL1R1, also known as interleukin-1 receptor type 1, associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. It is an important mediator involved in many cytokine induced immune and inflammatory responses. Recombinant human IL1R1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
37.4 kDa (324aa)
Additionnal Information
References & Citations
Beaulieu LM., et al. (2014) Arterioscler. Thromb. Vasc. Biol. 34: (3) 552-564.; ; Moos V., et al. (2000) Arthritis Rheum. 43 (11) :2417-22.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_000868.1
Uniprot Accession Number
P14778
Species
Human
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