Recombinant human Growth Hormone R/GHR protein

GHR, also known as growth hormone receptor, is a member of the cytokine receptor family. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, growth hormone acts as an antagonist because of a large difference in affinities at the respective binding sites. This antagonist action can be enhanced further by reducing binding in the low affinity binding site. Recombinant human GHR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Human Growth Hormone R/GHR in inhibit the cell growth using Nb2-11 Rat lymphoma cells in the presence of 1.25 ng/mL of human growth hormone. The ED50 range ≤ 10 ng/mL.

Product Name Alternative

GHR, GHBP, GHIP

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Bioactivity

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Bioactivity

Measured by ability to inhibit GH-induced proliferation assay using Nb2-11 Rat lymphoma cells in the presence of 1.25 ng/mL of human growth hormone. The ED50 range ≤ 10 ng/mL.

Molecular Weight

29.4 kDa (254aa)

Additionnal Information

Growth Hormone GHR, GHR, GHBP, GHIP, ATGP3207-10 µg, ATGP3207-20 µg, ATGP3207-50 µg, ATGP3207-100 µg, ATGP3207-250 µg, ATGP3207-500 µg, ATGP3207-1 mg, ATGP3207-10, ATGP3207-20, ATGP3207-50, ATGP3207-100, ATGP3207-250, ATGP3207-500, ATGP3207-1