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Recombinant mouse TIE2/TEK protein

TEK, also known as angiopoietin-1 receptor isoform 2, is cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4. It regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton. This protein effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Recombinant mouse TEK, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

TEK, TEK receptor tyrosine kinase, VMCM, venous malformations, multiple cutaneous and mucosal, TEK tyrosine kinase, endothelial, TIE2, TIE-2, VMCM1, CD202b, angiopoietin-1 receptor, Hyk, AA517024, STK1, p140 TEK

Expression System

Baculovirus

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

81.6 kDa (730aa)

Additionnal Information

Angiopoietin1 receptor, Tek, Hyk, Tie-2, Tie2, CD202b, AA517024, STK1, ATGP3190-10 µg, ATGP3190-20 µg, ATGP3190-50 µg, ATGP3190-100 µg, ATGP3190-250 µg, ATGP3190-500 µg, ATGP3190-1 mg, ATGP3190-10, ATGP3190-20, ATGP3190-50, ATGP3190-100, ATGP3190-250, ATGP3190-500, ATGP3190-1

References & Citations

Horita K et al., (1992) Biochem. Biophys. Res. Commun. 189 (3) :1747-1753.; ; Dumont DJ et al., (1992) Oncogene 7 (8) :1471-1480.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cardiovascular

NCBI Accession Number

NP_001277478

Uniprot Accession Number

Q02858

Species

Mouse

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