Recombinant mouse DLL4 protein
DLL4, also known as delta-like protein 4, is involved in the Notch signaling pathway as Notch ligand. Therefore it negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, it inhibits V2a interneuron fate. Recombinant mouse DLL4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Dll4, Delta4
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
55.8 kDa (512aa)
Additionnal Information
References & Citations
Luo H., et al. (2011) Proc Natl Acad Sci U S A. 109:E553-E562.; ; John R. Shutter., et al. (2000) Genes Dev. 14:1313-1318.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_062327
Uniprot Accession Number
Q9JI71
Species
Mouse
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