Recombinant human SYT11 protein

SYT11 also known as synaptotagmin-11. The protein may be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. A synaptotagmin potentially involved in Parkinson s desease and schizophrenia. Recombinant human SYT11, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Synaptotagmin-11, SYT12, sytXI

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Purity

> 80% by SDS-PAGE

Molecular Weight

47 kDa (418aa) confirmed by MALDI-TOF

Additionnal Information

SYT11, Synaptotagmin-11, SYT12, sytXI, ATGP3165-10 µg, ATGP3165-20 µg, ATGP3165-50 µg, ATGP3165-100 µg, ATGP3165-250 µg, ATGP3165-500 µg, ATGP3165-1 mg, ATGP3165-10, ATGP3165-20, ATGP3165-50, ATGP3165-100, ATGP3165-250, ATGP3165-500, ATGP3165-1

References & Citations

Huynh D P., et al. (2003) Hum Mol Genet. 12 (20) :2587-97; ; Glass AS., et al. (2004) J Neural Transm Suppl. (68) :21-8.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 50% glycerol

Scientific Category

Neuroscience

NCBI Accession Number

NP_689493

Uniprot Accession Number

Q9BT88

Species

Human

AA Sequence

WSCCHQQ AEKKQKNPPY KFIHMLKGIS IYPETLSNKK KIIKVRRDKD GPGREGGRRN LLVDAAEAGL LSRDKDPRGP SSGSCIDQLP IKMDYGEELR SPITSLTPGE SKTTSPSSPE EDVMLGSLTF SVDYNFPKKA LVVTIQEAHG LPVMDDQTQG SDPYIKMTIL PDKRHRVKTR VLRKTLDPVF DETFTFYGIP YSQLQDLVLH FLVLSFDRFS RDDVIGEVMV PLAGVDPSTG KVQLTRDIIK RNIQKCISRG ELQVSLSYQP VAQRMTVVVL KARHLPKMDI TGLSGNPYVK VNVYYGRKRI AKKKTHVKKC TLNPIFNESF IYDIPTDLLP DISIEFLVID FDRTTKNEVV GRLILGAHSV TASGAEHWRE VCESPRKPVA KWHSLSEY