Recombinant human Angiopoietin-like 3/ANGPTL3 protein

ANGPTL3 also known as Angiopoietin-related protein 3 is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN) -like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Recombinant human ANGPTL3, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

ANG-5, Angiopoietin 5, Angiopoietin-related protein 3, ANGPT5, ANGPTL3, ANL3, FHBL2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

27.7 kDa (239aa)

Additionnal Information

Angiopoietin-like3, Angiopoietin-related protein 3, ANG-5, ANGPT5, ANL3, FHBL2, ATGP3149-10 µg, ATGP3149-20 µg, ATGP3149-50 µg, ATGP3149-100 µg, ATGP3149-250 µg, ATGP3149-500 µg, ATGP3149-1 mg, ATGP3149-10, ATGP3149-20, ATGP3149-50, ATGP3149-100, ATGP3149-250, ATGP3149-500, ATGP3149-1

References & Citations

Arca M., et al. (2013) Curr. Opin. Lipidol. 24 (4) :313-20; ; Quagliarini F Q., et al. (2012) Proc Natl Acad Sci. 109 (48) :19751-6

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_055310

Uniprot Accession Number

Q9Y5C1

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MPAECTTIYN RGEHTSGMYA IRPSNSQVFH VYCDVISGSP WTLIQHRIDG SQNFNETWEN YKYGFGRLDG EFWLGLEKIY SIVKQSNYVL RIELEDWKDN KHYIEYSFYL GNHETNYTLH LVAITGNVPN AIPENKDLVF STWDHKAKGH FNCPEGYSGG WWWHDECGEN NLNGKYNKPR AKSKPERRRG LSWKSQNGRL YSIKSTKMLI HPTDSESFE