Recombinant human Angiopoietin-like 3/ANGPTL3 protein
ANGPTL3 also known as Angiopoietin-related protein 3 is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN) -like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Recombinant human ANGPTL3, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
ANG-5, Angiopoietin 5, Angiopoietin-related protein 3, ANGPT5, ANGPTL3, ANL3, FHBL2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
27.7 kDa (239aa)
Additionnal Information
References & Citations
Arca M., et al. (2013) Curr. Opin. Lipidol. 24 (4) :313-20; ; Quagliarini F Q., et al. (2012) Proc Natl Acad Sci. 109 (48) :19751-6
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Apoptosis
NCBI Accession Number
NP_055310
Uniprot Accession Number
Q9Y5C1
Species
Human
AA Sequence
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