Recombinant human Kallikrein 13/KLK13 protein
KLK13, also known as kallikrein-13, belongs to Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK13 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. Recombinant human KLK13, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Specific activity is > 8,000 pmol/min/ug. One unit will hydrolyze 1.0 pmole of BAEE to Na-Benzoyl-L-arginine per minute at pH8.0 at 25C.
Product Name Alternative
Kallikrein related peptidase 13, Kallikrein-13 Kallikrein-like protein 4, KLK-L4
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Enzyme Activity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Bioactivity
Specific activity is > 8,000pmol/min/ug. One unit will hydrolyze 1.0pmole of BAEE to Na-Benzoyl-L-arginine per minute at pH8.0 at 25C.
Molecular Weight
29.7 kDa (267aa)
Additionnal Information
References & Citations
Yousef G.M. et al., (2000) J. Biol. Chem. 275:11891-11898.; ; Diamandis EP. et al., (2000) Trends Endocrinol. Metab. 11:54-60.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_056411
Uniprot Accession Number
Q9UKR3
Species
Human
AA Sequence
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