Recombinant rat IL-1Ra/IL1RN protein

Il1rn also known as Interleukin-1 receptor antagonist protein is a member of the interleukin 1 cytokine family. Il1rn may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is no limit the pro-inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes. Il1rn is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Recombinant rat Il1rn, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, IL1 inhibitor, IL1RA

Expression System

E.coli

Antigen Species

Rat

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Purity

> 90% by SDS-PAGE

Molecular Weight

19.8 kDa (175aa) confirmed by MALDI-TOF

Additionnal Information

IRAP, Interleukin-1 receptor antagonist protein, Interleukin1 receptor antagonist protein, Interleukin 1 receptor antagonist protein, IL-1RN, IL-1ra, IL1RA, IL1F3, IL1 R A, IL1 inhibitor, IL 1RN, IL 1RA, IL 1 RA, IL 1 R A, ICIL-1RA, ICIL 1RA, ATGP3127-10 µg, ATGP3127-20 µg, ATGP3127-50 µg, ATGP3127-100 µg, ATGP3127-250 µg, ATGP3127-500 µg, ATGP3127-1 mg, ATGP3127-010, ATGP3127-020, ATGP3127-050, ATGP3127-100, ATGP3127-250, ATGP3127-500, ATGP3127-01M

References & Citations

Steinkasserer A., et al. (1992) Genomics. 13 (3) :654-7. ; ; Langdahl BL., et al. (2000) J Bone Miner Res. 15 (3) : 403-14.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT

Scientific Category

Immunology

NCBI Accession Number

NP_071530

Uniprot Accession Number

P25086

Species

Rat

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHPAGKRP CKMQAFRIWD TNQKTFYLRN NQLIAGYLQG PNTKLEEKID MVPIDFRNVF LGIHGGKLCL SCVKSGDDTK LQLEEVNITD LNKNKEEDKR FTFIRSETGP TTSFESLACP GWFLCTTLEA DHPVSLTNTP KEPCTVTKFY FQEDQ