Recombinant rat IL-1Ra/IL1RN protein
Il1rn also known as Interleukin-1 receptor antagonist protein is a member of the interleukin 1 cytokine family. Il1rn may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is no limit the pro-inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes. Il1rn is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Recombinant rat Il1rn, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, IL1 inhibitor, IL1RA
Expression System
E.coli
Antigen Species
Rat
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Purity
> 90% by SDS-PAGE
Molecular Weight
19.8 kDa (175aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Steinkasserer A., et al. (1992) Genomics. 13 (3) :654-7. ; ; Langdahl BL., et al. (2000) J Bone Miner Res. 15 (3) : 403-14.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT
Scientific Category
Immunology
NCBI Accession Number
NP_071530
Uniprot Accession Number
P25086
Species
Rat
AA Sequence
Frequently Asked Questions
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