Recombinant human JNK1 protein
MAPK8 also known as mitogen-activated protein kinase 8 JNK beta 2. MAPK8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. Recombinant human MAPK8, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Mitogen-activated protein kinase 8 JNK beta 2, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Purity
> 85% by SDS-PAGE
Molecular Weight
50.5 kDa (450aa)
Additionnal Information
References & Citations
Jha A., et al. (2014) EMBO J. 33 (5), 501-511; ; Misheva M., et al. (2014) Biochim. Biophys. Acta 1843 (2), 253-264;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001265476
Uniprot Accession Number
P45983
Species
Human
AA Sequence
Frequently Asked Questions
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