Recombinant human IFIT3 protein

IFIT3 also known as Interferon-induced protein with tetratricopeptiede repeats 3 isoform a. IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. IFIT3 is significantly induced upon RNA virus infection. Ectopic expression or knockdown of IFIT3 could, respectively, enhance or impair IRF3-mediated gene expression. Recombinant human IFIT3 was expressed in E. coli and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

Interferon-induced protein with tetratricopeptiede repeats 3 isoform a, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Purity

> 85% by SDS-PAGE

Molecular Weight

58.4 kDa (513aa)

Additionnal Information

IFIT3, Interferon-induced protein with tetratricopeptiede repeats 3 isoform a, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, ATGP3114-10 µg, ATGP3114-20 µg, ATGP3114-50 µg, ATGP3114-100 µg, ATGP3114-250 µg, ATGP3114-500 µg, ATGP3114-1 mg, ATGP3114-10, ATGP3114-20, ATGP3114-50, ATGP3114-100, ATGP3114-250, ATGP3114-500, ATGP3114-1

References & Citations

Fensterl V., et al. (2011) J. Interferon Cytokine Res. 31:71-78.; ; Liu X.Y., et al. (2011) J. Immunol. 187:2559-2568.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001540

Uniprot Accession Number

O14879

Species

Human

AA Sequence

MSEVTKN SLEKILPQLK CHFTWNLFKE DSVSRDLEDR VCNQIEFLNT EFKATMYNLL AYIKHLDGNN EAALECLRQA EELIQQEHAD QAEIRSLVTW GNYAWVYYHL GRLSDAQIYV DKVKQTCKKF SNPYSIEYSE LDCEEGWTQL KCGRNERAKV CFEKALEEKP NNPEFSSGLA IAMYHLDNHP EKQFSTDVLK QAIELSPDNQ YVKVLLGLKL QKMNKEAEGE QFVEEALEKS PCQTDVLRSA AKFYRRKGDL DKAIELFQRV LESTPNNGYL YHQIGCCYKA KVRQMQNTGE SEASGNKEMI EALKQYAMDY SNKALEKGLN PLNAYSDLAE FLETECYQTP FNKEVPDAEK QQSHQRYCNL QKYNGKSEDT AVQHGLEGLS ISKKSTDKEE IKDQPQNVSE NLLPQNAPNY WYLQGLIHKQ NGDLLQAAKC YEKELGRLLR DAPSGIGSIF LSASELEDGS EEMGQGAVSS SPRELLSNSE QLN