Recombinant human ALK-6/BMPR1B protein
BMPR1B also known as bone morphogenetic protein receptor type-1B isoform b. BMPR1B is on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. It's receptor for BMP7/OP-1 and GDF5. Recombinant human BMPR1B was expressed in E. coli and purified by using conventional chromatography techniques
Product Specifications
Product Name Alternative
Bone morphogenetic protein receptor type-1B isoform b, ALK-6, ALK6, CDw293, BMP type-1B receptor, BMPR-1B
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
15.1 kDa (136aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Ide H., et al. (1997) Oncogene 14:1377-1382.; ; Greenman C., et al. (2007) Nature 446:153-158.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT, 0.1mM PMSF
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_001243723
Uniprot Accession Number
O00238
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHR
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