Recombinant human beta-Sarcoglycan/SGCB protein

SGCB also known as beta-sarcoglycan, is a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy. Recombinant human SGCB protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Beta-sarcoglycan, A3b, LGMD2E, SGC, Beta-SG, 43 kDa dystrophin-associated glycoprotein, 43DAG

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

27.8 kDa (255aa)

Additionnal Information

SGCB, Beta-sarcoglycan, A3b, LGMD2E, SGC, Beta sarcoglycan, ATGP3095-10 µg, ATGP3095-20 µg, ATGP3095-50 µg, ATGP3095-100 µg, ATGP3095-250 µg, ATGP3095-500 µg, ATGP3095-1 mg, ATGP3095-010, ATGP3095-020, ATGP3095-050, ATGP3095-100, ATGP3095-250, ATGP3095-500, ATGP3095-01M

References & Citations

Lim L.E., et al. (1995) Nat. Genet. 11:257-265; ; Bonnemann C.G.., et al. (1996) Hum. Mol. Genet. 5:1953-1961

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_000223

Uniprot Accession Number

Q16585

Species

Human

AA Sequence

WAVIRIG PNGCDSMEFH ESGLLRFKQV SDMGVIHPLY KSTVGGRRNE NLVITGNNQP IVFQQGTTKL SVENNKTSIT SDIGMQFFDP RTQNILFSTD YETHEFHLPS GVKSLNVQKA STERITSNAT SDLNIKVDGR AIVRGNEGVF IMGKTIEFHM GGNMELKAEN SIILNGSVMV STTRLPSSSS GDQLGSGDWV RYKLCMCADG TLFKVQVTSQ NMGCQISDNP CGNTH