Recombinant human FGB protein
FGB also known as fibrinogen beta chain isoform 1 found in humans and most other vertebrates with a similar system of blood coagulation. FGB is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Recombinant human FGB protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Fibrinogen beta chain isoform 1, HEL-S-78p
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
40kDa (351aa)
Additionnal Information
References & Citations
Doolittle R.F., et al. (1984) Annu. Rev. Biochem. 53:195-229; ; Spraggon G., et al. (1997) Nature 389:455-462
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_005132
Uniprot Accession Number
P02675
Species
Human
AA Sequence
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