Recombinant mouse Lipocalin-2/NGAL protein
Lcn2 also known as neutrophil gelatinase-associated lipocalin, belongs to the calycin superfamily and Lipocalin family. LCN2 is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. The binding of LCN2 to bacterial siderophores is important in the innate immune response to bacterial infection. Also LCN2 functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF alpha) in humans. Recombinant mouse Lcn2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Neutrophil gelatinase-associated lipocalin, 24p3, AW212229, Sip24
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
23.3 kDa (203aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Yang J., et al. (2002) Mol. Cell 10:1045-1056.; ; Flo T.H., et al. (2004) Nature 432:917-921.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT
Scientific Category
Immunology
NCBI Accession Number
NP_032517
Uniprot Accession Number
P11672
Species
Mouse
AA Sequence
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