Recombinant human IL-12R beta/IL12RB1 protein
IL12RB1, also known as Interleukin-12 receptor subunit beta-1, is a intercellular adhesion molecule 1. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. It forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this protein and IL12RB2 was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Recombinant human IL12RB1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
58.4 kDa (528aa)
Additionnal Information
References & Citations
Van de Vosse E. et al. (2003) Immunogenetics. 54 (12) :817-29.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol, 1mM EDTA, 0.1mM PMSF.
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_005526.1
Uniprot Accession Number
P42701
Species
Human
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