Recombinant human IL-28B/IFNL3 protein
IFNL3, also known as Interferon lambda-3, is a secreted protein which belongs to the IL-28/IL-29 family. It is a cytokine with immunomodulatory activity. It up-regulates MHC class I antigen expression. This protein displays potent antiviral activity and antitumor activity. It seems to signal through the Jak-STAT pathway. It also contributes to viral resistance and is known to be upregulated by interferons and by RNA virus infection. Recombinant human IFNL3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Cytokine Zcyto22, IL28B, IL-28B, IL28C, IL-28C, Interferon lambda-3, Interleukin-28B, Interleukin-28C, ZCYTO22
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
20.4 kDa (181aa)
Additionnal Information
References & Citations
Kamal SM. et al. (2014) Am J Gastroenterol. 109 (2) :199-211.; ; Frizon K. et al. (2014) Braz J Infect Dis. 18 (2) :229-30.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM EDTA, 0.1mM PMSF.
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_742151.2
Uniprot Accession Number
Q8IZI9
Species
Human
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