Recombinant mouse SOD2/Mn-SOD protein
Sod2 also known as superoxide dismutase [Mn], mitochondrial, is a member of the iron/manganese superoxide dismutase family. It is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this protein have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Recombinant mouse Sod2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Superoxide dismutase [Mn] mitochondrial, Superoxide dismutase [Mn], mitochondrial, superoxide dismutase 2, mitochondrial, MnSOD, Sod-2
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
24.6 kDa (221aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Cheng Y., et al. (2014) J. Neuroimmunol. 269 (1-2), 38-43
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT
Scientific Category
Redox Proteins
NCBI Accession Number
NP_038699
Uniprot Accession Number
P09671
Species
Mouse
AA Sequence
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