Recombinant human IL-13R alpha 1/IL13RA1 protein

IL13RA1, also known as Interleukin-13 receptor subunit alpha-1, is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. It is essential for allergen-induced airway hyperactivity and mucus hypersecretion. Recombinant human IL13RA1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin 13 receptor subunit alpha 1, IL-13 receptor subunit alpha-1, IL-13R subunit alpha-1, IL-13R-alpha-1, Cancer/testis antigen 19, CT19, CD213a1, IL13R, IL13RA, NR4

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

37.7 kDa (328aa)

Additionnal Information

IL13 R a1, Interleukin-13 receptor subunit alpha-1, CD213A1, IL-13Ra, NR404235, ATGP3068-10 µg, ATGP3068-20 µg, ATGP3068-50 µg, ATGP3068-100 µg, ATGP3068-250 µg, ATGP3068-500 µg, ATGP3068-1 mg, ATGP3068-10, ATGP3068-20, ATGP3068-50, ATGP3068-100, ATGP3068-250, ATGP3068-500, ATGP3068-1

References & Citations

Liu, H. et al. (2000) . Cancer Immunol. Immunother. 49:319-324.; ; Debinski, W. et al. (2000) . Mol. Med. 6:440-449.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4)

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_001551

Uniprot Accession Number

P78552

Species

Human

AA Sequence

GGGGAAPTET QPPVTNLSVS VENLCTVIWT WNPPEGASSN CSLWYFSHFG DKQDKKIAPE TRRSIEVPLN ERICLQVGSQ CSTNESEKPS ILVEKCISPP EGDPESAVTE LQCIWHNLSY MKCSWLPGRN TSPDTNYTLY YWHRSLEKIH QCENIFREGQ YFGCSFDLTK VKDSSFEQHS VQIMVKDNAG KIKPSFNIVP LTSRVKPDPP HIKNLSFHND DLYVQWENPQ NFISRCLFYE VEVNNSQTET HNVFYVQEAK CENPEFERNV ENTSCFMVPG VLPDTLNTVR IRVKTNKLCY EDDKLWSNWS QEMSIGKKRN STHHHHHH