Recombinant human SNX5 protein
SNX5 also known as sorting nexin-5, is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. Recombinant human SNX5, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Sorting nexin-5 isoform a, Sorting nexin 5, snx 5
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
49.2 kDa (427aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Wassmer T., et al. (2007) J Cell Sci. 120:45-54; ; Otsuki T., et al. (1999) Biochem Biophys Res Commun. 265:630-635.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_689413
Uniprot Accession Number
Q9Y5X3
Species
Human
AA Sequence
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