Recombinant human UBLCP1 protein

UBLCP1 also known as ubiquitin-like domain-containing CTD phosphatase 1. This protein dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome. Recombinant human UBLCP1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Ubiquitin-like domain-containing CTD phosphatase 1, CPUB1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

39.2 kDa (341aa) confirmed by MALDI-TOF

Additionnal Information

UBLCP1, Ubiquitin-like domain-containing CTD phosphatase 1, CPUB1, ATGP3064-10 µg, ATGP3064-20 µg, ATGP3064-50 µg, ATGP3064-100 µg, ATGP3064-250 µg, ATGP3064-500 µg, ATGP3064-1 mg, ATGP3064-10, ATGP3064-20, ATGP3064-50, ATGP3064-100, ATGP3064-250, ATGP3064-500, ATGP3064-1

References & Citations

Zheng H., et al. (2005) Biochem. Biophys. Res. Commun. 331:1401-1407

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_659486

Uniprot Accession Number

Q8WVY7

Species

Human

AA Sequence

MALPIIV KWGGQEYSVT TLSEDDTVLD LKQFLKTLTG VLPERQKLLG LKVKGKPAEN DVKLGALKLK PNTKIMMMGT REESLEDVLG PPPDNDDVVN DFDIEDEVVE VENREENLLK ISRRVKEYKV EILNPPREGK KLLVLDVDYT LFDHRSCAET GVELMRPYLH EFLTSAYEDY DIVIWSATNM KWIEAKMKEL GVSTNANYKI TFMLDSAAMI TVHTPRRGLI DVKPLGVIWG KFSEFYSKKN TIMFDDIGRN FLMNPQNGLK IRPFMKAHLN RDKDKELLKL TQYLKEIAKL DDFLDLNHKY WERYLSKKQG Q