Recombinant human Langerin/CD207 protein
CD207 also known as C-type lectin domain family 4 member K. is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it's known by the name C-type lectin domain family 4 member K (CD antigen CD207) . It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Recombinant human CD207, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
C-type lectin domain family 4 member K, C-type lectin domain family 4 member K, CLEC4K
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
32.2 kDa (287aa)
Additionnal Information
References & Citations
Feinberg H., et al. (2013) J. Biol. Chem. 288 (52), 36762-36771; ; Lauc G., et al. (2013) PLoS Genet. 9 (1), E1003225;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_056532
Uniprot Accession Number
Q9UJ71
Species
Human
AA Sequence
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