Recombinant human IL-38/IL-1F10 protein

IL1F10 also known as interleukin-1 family member 10. IL1F10 is cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. It reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. It increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS) and ligand for IL-36R/IL1RL2. Recombinant human IL1F10 was expressed in E. coli and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

Interleukin 1 family member 10, Family of interleukin 1-theta, FIL1 theta, Interleukin-1 HY2, IL-1HY2, Interleukin-1 theta, IL-1 theta, Interleukin-38, IL-38, FIL1T, Interleukin-1 receptor antagonist FKSG75

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

16.9 kDa (152aa) confirmed by MALDI-TOF

Additionnal Information

IL38, IL1F10, Interleukin-1 family member 10, Interleukin-1 family member 10, FIL1-theta, FKSG75, IL1HY2, IL-38, IL1-theta, IL1HY2, ATGP3044-10 µg, ATGP3044-ㅁIL38, Interleukin-1 family member 10, Interleukin-1 family member 10, FIL1-theta, FKSG75, IL1HY2, IL-38, IL1-theta, IL1HY2, Macrophag Interleukin-1 2, ATGP3044-10 µg, ATGP3044-20 µg, ATGP3044-50 µg, ATGP3044-100 µg, ATGP3044-250 µg, ATGP3044-500 µg, ATGP3044-1 mg, ATGP3044-010, ATGP3044-020, ATGP3044-050, ATGP3044-100, ATGP3044-250, ATGP3044-500, ATGP3044-01M 20 µg, ATGP3044-50 µg, ATGP3044-100 µg, ATGP3044-250 µg, ATGP3044-500 µg, ATGP3044-1 mg, ATGP3044-10, ATGP3044-20, ATGP3044-50, ATGP3044-100, ATGP3044-250, ATGP3044-500, ATGP3044-1

References & Citations

Bensen J.T., et al. (2001) J. Interferon Cytokine Res. 21:899-904.; ; van de Veerdonk F.L., et al. (2012) Proc. Natl. Acad. Sci. u.S.A. 109:3001-3005.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4)

Scientific Category

Immunology

NCBI Accession Number

NP_115945.3

Uniprot Accession Number

Q8WWZ1

Species

Human

AA Sequence

MCSLPMARYY IIKYADQKAL YTRDGQLLVG DPVADNCCAE KICTLPNRGL DRTKVPIFLG IQGGSRCLAC VETEEGPSLQ LEDVNIEELY KGGEEATRFT FFQSSSGSAF RLEAAAWPGW FLCGPAEPQQ PVQLTKESEP SARTKFYFEQ SW