Recombinant human Granzyme H protein

GZMH also known as Granzyme H is essential for HBV eradication. The HBx protein (HBx), required for the replication of HBV, is cleaved at Met (79) by GZMH. GZMH inhibitor can abolish GZNH- and lymphokine-activated killer cell-mediated HBx degradation and HBV clearance. An HBx-deficient HBV is resistant to GzmH- and lymphokine-activated killer cell-mediated viral clearance. Recombinant human GZMH, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Granzyme H isoform 1, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

27.5 kDa (248aa)

Additionnal Information

Granzyme H, Granzyme H isoform 1, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2, ATGP3040-10 µg, ATGP3040-20 µg, ATGP3040-50 µg, ATGP3040-100 µg, ATGP3040-250 µg, ATGP3040-500 µg, ATGP3040-1 mg, ATGP3040-10, ATGP3040-20, ATGP3040-50, ATGP3040-100, ATGP3040-250, ATGP3040-500, ATGP3040-1

References & Citations

Ewen CL., et al. (2013) Mol. Immunol. 54 (3-4), 309-318 ; ; Wang L., et al. (2012) J. Immunol. 190 (3), 1319-1330 ;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_219491

Uniprot Accession Number

P20718

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MEIIGGHEAK PHSRPYMAFV QFLQEKSRKR CGGILVRKDF VLTAAHCQGS SINVTLGAHN IKEQERTQQF IPVKRPIPHP AYNPKNFSND IMLLQLERKA KWTTAVRPLR LPSSKAQVKP GQLCSVAGWG YVSMSTLATT LQEVLLTVQK DCQCERLFHG NYSRATEICV GDPKKTQTGF KGDSGGPLVC KDVAQGILSY GNKKGTPPGV YIKVSHFLPW IKRTMKRL