Recombinant human Granzyme H protein
GZMH also known as Granzyme H is essential for HBV eradication. The HBx protein (HBx), required for the replication of HBV, is cleaved at Met (79) by GZMH. GZMH inhibitor can abolish GZNH- and lymphokine-activated killer cell-mediated HBx degradation and HBV clearance. An HBx-deficient HBV is resistant to GzmH- and lymphokine-activated killer cell-mediated viral clearance. Recombinant human GZMH, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Granzyme H isoform 1, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
27.5 kDa (248aa)
Additionnal Information
References & Citations
Ewen CL., et al. (2013) Mol. Immunol. 54 (3-4), 309-318 ; ; Wang L., et al. (2012) J. Immunol. 190 (3), 1319-1330 ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Apoptosis
NCBI Accession Number
NP_219491
Uniprot Accession Number
P20718
Species
Human
AA Sequence
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