Recombinant human Glucuronosyltransferase 1A1/UGT1A1 protein

UGT1A1 also known as uDP-glucuronosyltransferase 1-1. uGT1A1 is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. It is also able to catalyze glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Recombinant human uGT1A1, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

UDP-glucuronosyltransferase 1-1, uDP-glucuronosyltransferase 1-1, BILIQTL1, GNT1, HuG-BR1, uDPGT, uDPGT 1-1, uGT1, uGT1A

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

54.7 kDa (488aa)

Additionnal Information

Glucuronosyltransferase1A1, UGT1A1, uDP-glucuronosyltransferase 1-1, uDP-glucuronosyltransferase 1-1, BILIQTL1, GNT1, HuG-BR1, uDPGT, uDPGT 1-1, uGT1, uGT1A, ATGP3014-10 µg, ATGP3014-20 µg, ATGP3014-50 µg, ATGP3014-100 µg, ATGP3014-250 µg, ATGP3014-500 µg, ATGP3014-1 mg, ATGP3014-10, ATGP3014-20, ATGP3014-50, ATGP3014-100, ATGP3014-250, ATGP3014-500, ATGP3014-1

References & Citations

Udomuksorn W., et al. (2007) Pharmacogenet. Genomics 17:1017-1029

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Metabolism

NCBI Accession Number

NP_000454

Uniprot Accession Number

P22309

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSHAGKILL IPVDGSHWLS MLGAIQQLQQ RGHEIVVLAP DASLYIRDGA FYTLKTYPVP FQREDVKESF VSLGHNVFEN DSFLQRVIKT YKKIKKDSAM LLSGCSHLLH NKELMASLAE SSFDVMLTDP FLPCSPIVAQ YLSLPTVFFL HALPCSLEFE ATQCPNPFSY VPRPLSSHSD HMTFLQRVKN MLIAFSQNFL CDVVYSPYAT LASEFLQREV TVQDLLSSAS VWLFRSDFVK DYPRPIMPNM VFVGGINCLH QNPLSQEFEA YINASGEHGI VVFSLGSMVS EIPEKKAMAI ADALGKIPQT VLWRYTGTRP SNLANNTILV KWLPQNDLLG HPMTRAFITH AGSHGVYESI CNGVPMVMMP LFGDQMDNAK RMETKGAGVT LNVLEMTSED LENALKAVIN DKSYKENIMR LSSLHKDRPV EPLDLAVFWV EFVMRHKGAP HLRPAAHDLT WYQYHSLD