Recombinant human PDGF-B protein
PDGFB, also known as, Platelet-derived growth factor subunit B isoform 2, is a member of Platelet derived growth factor (PDGF) family. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. Recombinant human PDGFB, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Platelet-derived growth factor subunit B isoform 2, Platelet-derived growth factor subunit B isoform 2, c-sis, IBGC5, PDGF-2, PDGF2, SIS, SSV
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
14.7 kDa (130aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Van Steensel L., et al. (2012) J Clin Endocrinol Metab. 97 (6) : 37062-37071.; ; Malabanan KP, et al. (2012) Am J Pathol. 180 (6) : 2590-7.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_148937.1
Uniprot Accession Number
P01127
Species
Human
AA Sequence
CKTRTEVFE ISRRLIDRTN ANFLVWPPCV EVQRCSGCCN NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF KKATVTLEDH LACKCETVAA ARPVTRSPGG SQEQRAKTPQ
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