Recombinant mouse IL-18 protein
IL18 (Interleukin18), previously known as interferon-gamma (IFN-gamma) -inducing factor, is an activator of NK cells and a co-inducer of Th1 cytokines. IL18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. Recombinant mouse IL18 was expressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Product Specifications
Product Name Alternative
Interleukin 18, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Igif
Expression System
E.coli
Antigen Species
Mouse
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
18.2 kDa (158aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Yoshimoto T., et al. (1998) J. Immunol, 161, 3400. ; ; Gracie JA ., et al. (2003) J Leukoc Biol. 73,213.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_032386
Uniprot Accession Number
P70380
Species
Mouse
AA Sequence
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