Recombinant human PTPN4 protein

PTPN4 also known as Protein tyrosine phosphatase, non-receptor type 4, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN4 is a widely expressed non-receptor protein tyrosine phosphatase. It has been shown to interact with glutamate receptor delta 2 and epsilon, and may affect glutamate receptors signaling and/or in regulation of their activities through tyrosine dephosphorylation. Recombinant human PTPN4, fused to His-tag at N-terminus, was expressed in E. coli

Product Specifications

Product Name Alternative

Protein tyrosine phosphatase non-receptor type 4, Protein tyrosine phosphatase, non-receptor type 4, PTPMEG, PTPMEG1, MEG

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

32 kDa (280aa)

Additionnal Information

PTPN4, Protein tyrosine phosphatase non-receptor type 4, Protein tyrosine phosphatase, non-receptor type 4, PTPMEG, PTPMEG1, MEG, ATGP3005-10 µg, ATGP3005-20 µg, ATGP3005-50 µg, ATGP3005-100 µg, ATGP3005-250 µg, ATGP3005-500 µg, ATGP3005-1 mg, ATGP3005-10, ATGP3005-20, ATGP3005-50, ATGP3005-100, ATGP3005-250, ATGP3005-500, ATGP3005-1

References & Citations

Babault N., et al. (2011) Structure. 19 (10) :1518-24; ; Zhou J., et al. (2013) Cell Mol Biol Lett. 18 (2) : 297-314.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_002821

Uniprot Accession Number

P29074

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MVLTQFDQLY RKKPGMTMSC AKLPQNISKN RYRDISPYDA TRVILKGNED YINANYINME IPSSSIINQY IACQGPLPHT CTDFWQMTWE QGSSMVVMLT TQVERGRVKC HQYWPEPTGS SSYGCYQVTC HSEEGNTAYI FRKMTLFNQE KNESRPLTQI QYIAWPDHGV PDDSSDFLDF VCHVRNKRAG KEEPVVVHCS AGIGRTGVLI TMETAMCLIE CNQPVYPLDI VRTMRDQRAM MIQTPSQYRF VCEAILKVYE