Recombinant human CLEC-2/CLEC1B protein

CLEC1B also known as C-type lectin domain family 1 member B. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Recombinant human CLEC1B, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

C-type lectin domain family 1 member B, CLEC2, CLEC-2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

23.1 kDa (198aa)

Additionnal Information

810061I13Rik, CLEC1B, CLEC2, CLEC-2, CLEC2B, C-type lectin domain family 1 member B, C-type lectin domain family 1 member B isoform a, PRO1384, ATGP3004-10 µg, ATGP3004-20 µg, ATGP3004-50 µg, ATGP3004-100 µg, ATGP3004-250 µg, ATGP3004-500 µg, ATGP3004-1 mg, ATGP3004-010, ATGP3004-020, ATGP3004-050, ATGP3004-100, ATGP3004-250, ATGP3004-500, ATGP3004-01M

References & Citations

Manne BK., et al. (2013) J. Biol. Chem. 288 (11), 7717-7726; ; Hughes CE., et al. (2013) J. Biol. Chem. 288 (7), 5127-5135

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_057593

Uniprot Accession Number

Q9P126

Species

Human

AA Sequence

SVMQRNY LQGENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSP CDTNWRYYGD SCYGFFRHNL TWEESKQYCT DMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWK WEDGSVISEN MFEFLEDGKG NMNCAYFHNG KMHPTFCENK HYLMCERKAG MTKVDQLP