Recombinant human PTDSR/JMJD6 protein
JMJD6 also known as bifunctional arginine demethylase and lysyl-hydroxylase JMJD6. JMJD6 acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2AF2/u2AF65 and LuC7L2, as a regulator of RNA splicing by mediating 5-hydroxylation of u2AF2/u2AF65, affecting the pre-mRNA splicing activity of u2AF2/u2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. Recombinant human JMJD6, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Jumonji domain containing 6, Arginine demethylase and lysine hydroxylase, Phosphatidylserine receptor, KIAA0585
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
50kDa (437aa)
Additionnal Information
References & Citations
Hong X. et al. (2010) Proc. Natl. Acad. Sci. u.S.A. 107:14568-14572.; ; Webby C.J. et al. (2009) Science 325:90-93.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol, 1mM DTT
Scientific Category
Apoptosis
NCBI Accession Number
NP_001074930
Uniprot Accession Number
Q6NYC1
Species
Human
AA Sequence
Frequently Asked Questions
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