Recombinant human IGFBP-3 protein
IGFBP3 also known as Insulin-like growth factor binding protein 3 isoform b precursor. They are structurally and functionally related to insulin but have a much higher growth-promoting activity. It may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. It stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. It may play a role in synapse maturation. Recombinant human IGFBP3, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Insulin-like growth factor binding protein 3 isoform b precursor, IBP3, BP-53
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
31 kDa (285aa)
Additionnal Information
References & Citations
Zoidis E., et al. (2011) Mol. Cell. Biochem. 348:33-42
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Apoptosis
NCBI Accession Number
NP_000589
Uniprot Accession Number
P17936
Species
Human
AA Sequence
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