Recombinant human AMPK alpha 1 protein
PRKAA1 also known as 5-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1. PRKAA1 is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK) . AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinasen activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Recombinant human PRKAA1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
PRKAA1, 5-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1, AMPK, AMPKa11
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
34.3 kDa (302aa)
Additionnal Information
References & Citations
Imamura K., et al. (2001) Biochem. Biophys. Res. Commun. 287:562-567; ; Yang W., et al. (2001) J. Biol. Chem. 276:38341-38344
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_006242.2
Uniprot Accession Number
Q13131
Species
Human
AA Sequence
Frequently Asked Questions
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