Recombinant human Activin A protein
INHBA also known as inhibin beta A chain. The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Recombinant human INHBA, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Inhibin beta A chain, EDF, FRP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
15.2 kDa (137aa)
Additionnal Information
References & Citations
Antsiferova M., et al. (2013) J. Immunol. 191 (12), 6147-6155; ; Woeckel VJ., et al. (2013) J. Cell. Physiol. 228 (11), 2167-2174
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_002183
Uniprot Accession Number
P08476
Species
Human
AA Sequence
GLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
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