Recombinant human Granzyme B protein
GZMB also known as granzyme B is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Recombinant human GZMB, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Granzyme B, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
27.8 kDa (248aa)
Additionnal Information
References & Citations
Xu W., et al. (2014) Eur. J. Immunol. 44 (1), 275-284; ; Fritsch K., et al. (2013) Ann. Hematol. 92 (12), 1603-1609
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Apoptosis
NCBI Accession Number
NP_004122
Uniprot Accession Number
P10144
Species
Human
AA Sequence
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