Recombinant human sFRP-5/SFRP5 protein

SARP3, also known as secreted frizzled-related protein 5, is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. Recombinant SFRP5, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Secreted frizzled-related protein 5, sFRP-5, Frizzled-related protein 1b, FRP-1b, Secreted apoptosis-related protein 3, SARP-3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

35 kDa (311aa)

Additionnal Information

SFRP5, Secreted frizzled-related protein 5, SARP3, ATGP2966-10 µg, ATGP2966-20 µg, ATGP2966-50 µg, ATGP2966-100 µg, ATGP2966-250 µg, ATGP2966-500 µg, ATGP2966-1 mg, ATGP2966-10, ATGP2966-20, ATGP2966-50, ATGP2966-100, ATGP2966-250, ATGP2966-500, ATGP2966-1

References & Citations

Veeck J, Geisler C, et al. (2008) . Carcinogenesis. 29 (5) :991-8.; ; urakami S, Shiina H, et al. (2006) . Clin Cancer Res. 12 (7 Pt 1) :2109-16.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Stem cell

NCBI Accession Number

NP_003006

Uniprot Accession Number

Q5T4F7

Species

Human

AA Sequence

EEYDYYG WQAEPLHGRS YSKPPQCLDI PADLPLCHTV GYKRMRLPNL LEHESLAEVK QQASSWLPLL AKRCHSDTQV FLCSLFAPVC LDRPIYPCRS LCEAVRAGCA PLMEAYGFPW PEMLHCHKFP LDNDLCIAVQ FGHLPATAPP VTKICAQCEM EHSADGLMEQ MCSSDFVVKM RIKEIKIENG DRKLIGAQKK KKLLKPGPLK RKDTKRLVLH MKNGAGCPCP QLDSLAGSFL VMGRKVDGQL LLMAVYRWDK KNKEMKFAVK FMFSYPCSLY YPFFYGAAEP H