Recombinant mouse IL-34 protein
IL34 is a cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. This protein promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Recombinant Mouse IL34 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Interleukin-34, 2010004A03Rik
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
26.8 kDa (236aa)
Additionnal Information
References & Citations
Greter M, et al. (2012) Immunity 37 (6), 1050-1060
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_001128572
Uniprot Accession Number
Q8R1R4
Species
Mouse
AA Sequence
Frequently Asked Questions
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