Recombinant mouse IL-34 protein

IL34 is a cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. This protein promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Recombinant Mouse IL34 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Interleukin-34, 2010004A03Rik

Expression System

E.coli

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

26.8 kDa (236aa)

Additionnal Information

Interleukin34, Interleukin 34, Interleukin-34, 2010004A03Rik, ATGP2951-10 µg, ATGP2951-20 µg, ATGP2951-50 µg, ATGP2951-100 µg, ATGP2951-250 µg, ATGP2951-500 µg, ATGP2951-1 mg, ATGP2951-010, ATGP2951-020, ATGP2951-050, ATGP2951-100, ATGP2951-250, ATGP2951-500, ATGP2951-01M

References & Citations

Greter M, et al. (2012) Immunity 37 (6), 1050-1060

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_001128572

Uniprot Accession Number

Q8R1R4

Species

Mouse

AA Sequence

NENLEIWTL TQDKECDLTG YLRGKLQYKN RLQYMKHYFP INYRIAVPYE GVLRVANITR LQKAHVSERE LRYLWVLVSL NATESVMDVL LEGHPSWKYL QEVQTLLENV QRSLMDVEIG PHVEAVLSLL STPGLSLKLV RPKALLDNCF RVMELLYCSC CKQSPILKWQ DCELPRLHPH SPGSLMQCTA TNVYPLSRQT PTSLPGSPSS SHGSLP