Recombinant human NRF2/NFE2L2 protein
Nuclear factor (erythroid-derived 2) -like 2, also known as NRF2, is bZIP transcription factors that heterodimerize with Maf proteins to bind Mare sequences. The NRF proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. NRF2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1. Recombinant human NRF2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
NFE2 like bZIP transcription factor 2, Nuclear factor erythroid 2-related factor 2, NRF-2, NF-E2-related factor 2, HEBP1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
69.9 kDa (625aa)
Additionnal Information
References & Citations
Huang H C., et al. (2000) Proc Natl Acad Sci uSA. 97: 12475-12480.; ; Tsai P Y., et al. (2012) Arthritis Rheum. 64: 232-242.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Epigenetics and Nuclear Signaling
NCBI Accession Number
NP_006155.2
Uniprot Accession Number
Q16236
Species
Human
AA Sequence
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
P57 Kip2/Cdkn1c Recombinant Antibody, RBITC Conjugated