Recombinant human MKK6 protein
MAP2K6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MAP2K6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Recombinant human MAP2K6, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase kinase 6, MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
32.0 kDa (383aa)
Additionnal Information
References & Citations
Manning G., et al. (2002) Science 298 (5600) : 1912-34; ; Pearson G., et al. (2002) Endocr. Rev. 22 (2) : 153-83;
Other References
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Cell Cycle
NCBI Accession Number
NP_002749
Uniprot Accession Number
P52564
Species
Human
AA Sequence
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