Recombinant human MKK6 protein

MAP2K6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MAP2K6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Recombinant human MAP2K6, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase kinase 6, MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

32.0 kDa (383aa)

Additionnal Information

MKK6, Mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase kinase 6, MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, ATGP2942-10 µg, ATGP2942-20 µg, ATGP2942-50 µg, ATGP2942-100 µg, ATGP2942-250 µg, ATGP2942-500 µg, ATGP2942-1 mg, ATGP2942-10, ATGP2942-20, ATGP2942-50, ATGP2942-100, ATGP2942-250, ATGP2942-500, ATGP2942-1

References & Citations

Manning G., et al. (2002) Science 298 (5600) : 1912-34; ; Pearson G., et al. (2002) Endocr. Rev. 22 (2) : 153-83;

Other References

Kim DO, et al. TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection. (Int J Mol Sci. 2020) {https://pubmed.ncbi.nlm.nih.gov/33327533/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Cell Cycle

NCBI Accession Number

NP_002749

Uniprot Accession Number

P52564

Species

Human

AA Sequence

MLEPIMELGR GAYGVVEKMR HVPSGQIMAV KRIRATVNSQ EQKRLLMDLD ISMRTVDCPF TVTFYGALFR EGDVWICMEL MDTSLDKFYK QVIDKGQTIP EDILGKIAVS IVKALEHLHS KLSVIHRDVK PSNVLINALG QVKMCDFGIS GYLVDEVAKE IDAGCKPYMA PERINPELNQ KGYSVKSDIW SLGITMIELA ILRFPYDSWG TPFQQLKQVV EEPSPQLPAD KFSAEFVDFT SQCLKKNSKE RPTYPELMQH PFF