Recombinant human FOLR1 protein

FOLR1 is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This protein is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. Recombinant human FOLR1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Folate receptor alpha, FBP, FOLR

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

27 kDa (233aa)

Additionnal Information

FOLR1, Folate receptor alpha, FBP, FOLR, ATGP2938-10 µg, ATGP2938-20 µg, ATGP2938-50 µg, ATGP2938-100 µg, ATGP2938-250 µg, ATGP2938-500 µg, ATGP2938-1 mg, ATGP2938-10, ATGP2938-20, ATGP2938-50, ATGP2938-100, ATGP2938-250, ATGP2938-500, ATGP2938-1

References & Citations

Lacey S.W., et al. (1989) J. Clin. Invest. 84:715-720.; ; Orr R.B., et al. (1994) Cancer Res. 54:3905-3911.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_057936

Uniprot Accession Number

P15328

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSRIAWART ELLNVCMNAK HHKEKPGPED KLHEQCRPWR KNACCSTNTS QEAHKDVSYL YRFNWNHCGE MAPACKRHFI QDTCLYECSP NLGPWIQQVD QSWRKERVLN VPLCKEDCEQ WWEDCRTSYT CKSNWHKGWN WTSGFNKCAV GAACQPFHFY FPTPTVLCNE IWTHSYKVSN YSRGSGRCIQ MWFDPAQGNP NEEVARFYAA AMS