Recombinant human LZTFL1 protein

LZTFL1 is a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. LZTFL1 may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Recombinant human LZTFL1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Leucine zipper transcription factor-like protein 1, Leucine zipper transcription factor-like protein 1, BBS17

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

37 kDa (322aa) confirmed by MALDI-TOF

Additionnal Information

LZTFL1, Leucine zipper transcription factor-like protein 1, Leucine zipper transcription factor-like protein 1, BBS17, ATGP2929-10 µg, ATGP2929-20 µg, ATGP2929-50 µg, ATGP2929-100 µg, ATGP2929-250 µg, ATGP2929-500 µg, ATGP2929-1 mg, ATGP2929-10, ATGP2929-20, ATGP2929-50, ATGP2929-100, ATGP2929-250, ATGP2929-500, ATGP2929-1

References & Citations

Wei Q., et al. (2010) Cancer Res. 70 (7), 2942-2950

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT

Scientific Category

Epigenetics and Nuclear Signaling

NCBI Accession Number

NP_065080

Uniprot Accession Number

Q9NQ48

Species

Human

AA Sequence

MAELGLN EHHQNEVINY MRFARSKRGL RLKTVDSCFQ DLKESRLVED TFTIDEVSEV LNGLQAVVHS EVESELINTA YTNVLLLRQL FAQAEKWYLK LQTDISELEN RELLEQVAEF EKAEITSSNK KPILDVTKPK LAPLNEGGTA ELLNKEILRL QEENEKLKSR LKTIEIQATN ALDEKSKLEK ALQDLQLDQG NQKDFIKAQD LSNLENTVAA LKSEFQKTLN DKTENQKSLE ENLATAKHDL LRVQEQLHMA EKELEKKFQQ TAAYRNMKEI LTKKNDQIKD LRKRLAQYEP ED