Recombinant human TRIB3 protein
TRIB3, also known as tribbles pseudokinase 3, is a putative protein kinase that is induced by the transcription factor NF-kappaB. This protein is a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, it can negatively regulate the cell survival serine-threonine kinase AKT1. Recombinant human TRIB3 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Tribbles homolog 3, Tribbles homolog 3, C20orf97, NIPK, SINK, SKIP3, TRB3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
42.0 kDa (381aa)
Additionnal Information
References & Citations
Du K. et al. (2003) Science. 300:1574-1577.; ; Hegedus Z. et al. (2006) Cell Mol Life Sci. 63:1632-1641.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_066981
Uniprot Accession Number
Q96RU7
Species
Human
AA Sequence
Frequently Asked Questions
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